Natural Killer cells (NKC) are lymphocytes, an immune cell that fights infections and cancer. In some circumstances NKC may identify the early embryo as an early cancer and attack it, preventing a pregnancy from continuing.
NKC are the predominant leukocyte found in the lining of the uterus, the endometrium.
They increase in numbers around the time of implantation.
When they are present in normal numbers they aid the implantation of the embryo.
However, for reasons not fully understood, conditions prevail ,that allow the NKC to attack and destroy the pregnancy.
An endometrial biopsy taken on day 21 of the menstrual cycle allows assessment of the number of cells present.
If there is an excess of cells they may play a role in repeated implantation failure , (RIF) and recurrent spontaneous abortions (RSA).
I have been treating patients with these two conditions for the past four years with very good success.
I suppress the NKC with steroids, Intralipids and clexane.
Intralipids lower the activity of NKC allowing embryos to implant and develop normally.
Women who have suffered RSA or multiple failed IVF cycles as a result of abnormal NKC activity may benefit from this treatment.
Intralipids have been shown to lower the activity of NKC. Allowing embryos to implant and grow normally.